Toxic leukoencephalopathy refers to a rare but severe neurological condition that can occur in the context of drug use. It is characterized by damage to the brain's white matter, which consists of nerve fibers responsible for transmitting information between different regions of the brain. Drug-induced toxic leukoencephalopathy can result from the use of certain substances, including volatile solvents, inhalants, illicit drugs, and some prescription medications. The condition's pathophysiology involves toxic substances damaging the brain's myelin sheath, leading to impairments in cognition, motor skills, and sensory functions. Early recognition and cessation of the offending drug are crucial to prevent further damage and potentially reverse the condition's effects. As toxic leukoencephalopathy can cause severe and permanent neurological deficits, healthcare providers should be vigilant in recognizing any neurological symptoms in individuals with a history of drug use and consider the potential role of toxic substances as a cause.
More information can be found here: Toxic leukoencephalopathy [bccdc.ca]