EMR: Chest pain or signs and symptoms consistent with cardiac ischemia
EMR: chest pain or signs and symptoms consistent with cardiac ischemia
CliniCall consultation required prior to pediatric administration.
Chest pain in children is unlikely to be the result of ischemia; ASA is therefore not indicated unless there are rare, specific histories of disease.
ASA inhibits the formation of thromboxane A2, which is a potent platelet aggregator and vasoconstrictor. The platelet effects are irreversible, and last for the life of the platelet (7-10 days).
ASA can be toxic at doses higher than 150 mg/kg. Early symptoms include nausea, vomiting, diaphoresis, and tinnitus. Hyperventilation can occur.
ASA should not be used in children, teenagers, or young adults with chickenpox, influenza, or other flu-like illness due to the risk of the development of Reye syndrome.
Alcohol use can increase the risk of gastrointestinal bleeding.
The antiplatelet effects of ASA may increase the risk of bleeding, particularly in patients who are already taking anticoagulant medications. These risks must be balanced against the benefit of ASA in patients who are experiencing cardiac ischemia. CliniCall consultation recommended to discuss care planning options.