High alert medication
Controlled and targeted substance
General anesthetic
PCP: Analgesia
ACP: Induction and maintenance of anesthesia
ACP: Procedural sedation
ACP: Severe agitation or excited delirium syndrome
PCP: Analgesia
ACP: Analgesia
ACP: Procedural Sedation
ACP: Anesthesia Induction
ACP: Maintenance of Anesthesia
ACP: Excited Delirium
PCP: Analgesia (Ages 5-11 years)
ACP: Analgesia (Aged > 6 months)
ACP: Procedural Sedation
ACP: Excited Delirium
• Ketamine interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels
• At low doses it causes analgesia and higher doses lead to dissociation
Onset:
Peak:
Duration:
• Transient increases or decreases in blood pressure and heart rate
• Apnea and respiratory depression with rapid administration
• Hypersalivation
• Muscle rigidity
• During recovery, emergency reaction may occur including vivid dreams, confusion, excitement, hallucinations
• Spontaneous involuntary movements
• Injection site reactions
• Laryngospasm is a known and rare complication of ketamine
• administration; when it occurs, is usually transient
• Consider midazolam for management of emergence symptoms
Use with caution in: