Classification
High alert medication
Controlled and targeted substance
General anesthetic
Indications
PCP: Analgesia
ACP: Induction and maintenance of anesthesia
ACP: Procedural sedation
ACP: Severe agitation or excited delirium syndrome
Contraindications
- Hypersensitivity to ketamine
- Conditions where hypertension may be harmful such as cerebral vascular accident or severe cardiac disease
- PCP: Age < 5 years
- ACP: Age < 6 months
Adult dosages
PCP: Analgesia
- ⚠️ PCP: requires BCEHS-specific education (Flight Training Program; including IN ketAMINE endorsement)
- Intranasal
- Initial dose: 0.75 mg/kg IN (max dose 100mg); usual dose: 50-100 mg
- ☎️ Mandatory consult prior to administration with 1)CCP-A 2)EPOS 3) CliniCall
- May repeat 0.5 mg/kg after 20 minutes
- Consult as per above for additional dosing instructions. No maximum cumulative dose.
- Safety Alert: Remember to account for the 0.1 mL dead space in the MAD to ensure accurate dose is administered and documented.
- See PR11: Intranasal Medication Administration procedure
ACP: Analgesia
- Intravenous/Intraosseous
- 0.25mg/kg (max 35mg) IV/IO slow push q 20 minutes prn
- Intramuscular
- 0.25 - 0.5 mg/kg IM q 45 minutes prn
ACP: Procedural Sedation
- Intravenous/Intraosseous
- 0.1-0.5 mg/kg slow push every 60 seconds to effect
- Consider starting at 0.5 mg/kg; use subsequent doses of 0.25 mg/kg or less as needed
- Titrate to effect
ACP: Anesthesia Induction
- Shock index less than 1
- Shock index greater than 1
- 0.5-1 mg/kg IV/IO (may repeat at 2-5 minutes to a maximum total of 2 mg/kg)
ACP: Maintenance of Anesthesia
- Infusion: 2 mg/kg/hour IV/IO (range 0.5-4 mg/kg/hour IV/IO)
OR
- Direct: 0.5-1 mg/kg IV/IO q15 - 30 minutes
ACP: Excited Delirium
- Intramuscular
- 4-5 mg/kg bolus
- Maximum single/cumulative dose 500 mg
- Maximum volume of administration
- Deltoid: 2 mL
- Lateral thigh: 4-5 mL
- Gluteal: 5 mL
Pediatric Considerations And Dosing
PCP: Analgesia (Ages 5-11 years)
- ⚠️ PCP: requires BCEHS-specific education (Flight Training Program; including IN ketAMINE endorsement)
- Intranasal
- 1 mg/kg IN (Maximum 100mg)
- ☎️ Mandatory consult prior to administration with 1)CCP-A 2)EPOS 3) CliniCall
- May repeat 1 mg/kg IN after 20 minutes prn
- Consult as per above for additional dosing instructions. No maximum cumulative dose.
- Safety Alert: Remember to account for the 0.1 mL dead space in the MAD to ensure accurate dose is administered and documented.
- See PR11: Intranasal Medication Administration procedure
ACP: Analgesia (Aged > 6 months)
- Intravenous/Intraosseous
- 0.25 mg/kg (maximum 20mg) slow push q 20 minutes prn (Total max 0.6mg/kg)
- Intranasal
ACP: Procedural Sedation
ACP: Anesthesia Induction
- Stable hemodynamics
- Unstable hemodynamics
- 0.25-1 mg/kg IV/IO (may repeat at 2-5 minutes to a maximum total of 2 mg/kg)
ACP: Maintenance of Anesthesia
- Infusion: 5-20mcg/kg/min IV/IO
OR
- Direct: 0.5-1 mg/kg IV/IO q15 - 30 minutes
ACP: Excited Delirium
Preparation and Administration
Adult and Pediatric Standard Concentration
- 5mg/mL: Add 250mg to 50mL of NS
- 10mg/mL: Add 500mg to 50mL of NS
Slow push
- Administer over 60-90 seconds
Mechanism Of Action
• Ketamine interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels
• At low doses it causes analgesia and higher doses lead to dissociation
Pharmacokinetics
Onset:
- Intravenous: 30 seconds (anesthesia)
- Intramuscular: 3-4 minutes (anesthesia)
- Intranasal: 5-10 minutes (analgesia)
Peak:
Duration:
- Intravenous: 5-10 minutes (anesthesia); recovery 1-2 hours
- Intramuscular: 12-25 minutes; recovery 3-4 hours
- Intranasal: 45 minutes (analgesia)
Adverse Effects
• Transient increases or decreases in blood pressure and heart rate
• Apnea and respiratory depression with rapid administration
• Hypersalivation
• Muscle rigidity
• During recovery, emergency reaction may occur including vivid dreams, confusion, excitement, hallucinations
• Spontaneous involuntary movements
• Injection site reactions
• Laryngospasm is a known and rare complication of ketamine
• administration; when it occurs, is usually transient
Overdose
• Consider midazolam for management of emergence symptoms
Warning And Precautions
Use with caution in:
- Severe hypertension (systolic BP > 180 mmHg)
- Subarachnoid hemorrhage or epidural hematoma with severe hypertension
- Myocardial ischemia or cardiac arrhythmias