Antiepileptic

CCP: Status epilepticus

CCP: Seizure management

• Hypersensitivity to any component of the medication

Caution

• Renal dysfunction
• Psychiatric disorder

ADULTS:

Status epilepticus

• Dilute all doses in 100mL of NS immediately prior to administration
• Administer up to 3000mg over 5 minutes
• Administer 30001 - 4500mg over 10 minutes

Seizure management (maintenance)

• Doses up to 1500mg in 100mL of NS
• Doses above 1500mg in 250mL of NS
• Infuse over 15 minutes

PEDIATRICS:

• Dilute all doses in 100mL NS immediately prior to admnistration
• Infuse over 15 minutes

IV

• Onset 15-30 minutes

CNS

• Ataxia, weakness, fatigue, dizziness, drowsiness, headache
• Psychiatric symptoms including anxiety, anger, emotional lability, depression, suicidal ideation

GI

• Abdominal pain
• Nasopharyngitis

Derm

• Delayed hypersensitivity reactions ranging from mild maculopapular rash to severe cutaneous adverse reaction (toxic epidermal necrolysis) or Stevens Johnson Syndrome (SJS). Usual onset is 1-2 weeks after treatment initiation

• Use caution in patients with psychiatric disorders
• Dose reduction required in renal dysfunction

• CNS depressants may increase risk of drowsiness
• Many drug interactions possible but none are significant in the emergent management of seizures