Narcotic antagonist
FR: Reversal of respiratory depression caused by suspected narcotic intoxication
FR: Reversal of respiratory depression caused by suspected narcotic intoxication
EMR: Reversal of respiratory depression caused by suspected narcotic intoxication
Naloxone IM every 3 minutes as required; maximum 4 doses
PCP: Reversal of respiratory depression caused by suspected narcotic intoxication
Naloxone IM/IV every 3 minutes as required; maximum 4 doses
*Palliative patient populations: titrating 0.1mg IM/IV/min for opioid overdose in the palliative patient to reverse respiratory depression without interfering with pain contro
ACP: Reversal of respiratory depression caused by suspected narcotic intoxication
Titrate doses to improve spontaneous respiratory effort and minimize withdrawal symptoms.
Never administer naloxone to neonates
FR: Not authorized for use in pediatrics
EMR: Reversal of respiratory depression caused by suspected narcotic intoxication
Ampoule: 0.4 mg/mL in 1 mL ampoule
Vial: 1 mg/mL (2 mg in 2 mL vial)
Competitively antagonizes opioids bound to receptors in the central nervous system.
Some evidence exists that suggests naloxone may be heat sensitive, losing some potency after 4+ weeks of storage at temperatures consistently above 40°C. Degraded medication is unlikely to be harmful to patients, but may not carry the same clinical effects, thus requiring higher doses.