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PHENYLephrine

Sympathomimetic

ACP: Shock and hypotension following adequate volume replacement.

ACP: Shock and hypotension following adequate volume replacement.

100 mcg IV slow push every 2-5 minutes prn to maintain MAP greater than 65mmHg or perfusion
- Administer over 20-30 seconds
Use large vein in forearm; if possible, avoid hand, wrist , or antecubital fossa

Not authorized in pediatric patients; consider the use of push-dose epinephrine

Agonizes alpha-adrenergic receptors producing arterial vasoconstriction.

Intravenous:

Headache
Nervousness
Reflex bradycardia is common
Nausea and vomiting
Rapid administration of PHENYLephrine may result in the development of premature ventricular contractions, ventricular tachycardia, or hypertension
May produce significant peripheral or visceral vasoconstriction, reduced blood flow to vital organs, decreased renal perfusion and possibly reduced renal output and metabolic acidosis; these effects are more likely to occur in hypovolemic patients
Extravasation risk

Exercise caution when administering PHENYLephrine to patients with bradycardia, incomplete AV block, or other underlying cardiovascular disease.
PHENYLephrine carries a significant risk of sloughing and tissue necrosis if extravasation occurs. Ensure administration line is patent and free-flowing.
Rapid IV administration of PHENYLephrine may result in the development of premature ventricular contractions, ventricular tachycardia, or hypertension.