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Airway smooth muscle relaxant
Used in cardiac care to aid in treatment of VF and pulseless VT and for unstable Torsades de pointes.
In patients with perfusing rhythms it acts as a smooth muscle relaxant and can induce neuromuscular weakness and heart block therefore must be given slowly
Onset - Rapid
Peak - < 5 minutes
Duration - Duration of effect undetermined in cardiac arrest.
Onset is 20 to 30 minutes when administering as an infusion to asthma patients.
VF or pulseless VT.
Recurrent intermittent episodes of wide complex tachycardia.
Unstable Torsades de pointes with recurrent periods of loss of perfusing pulse.
May be administered as an infusion to patients with asthma refractory to bronchodilation.
Hypersensitivity to Magnesium Sulfate.
degree AV block.
May prolong effect of non-depolarizing neuromuscular blockers.
May enhance actions of calcium channel blockers.
In patients with perfusing rhythm: hypotension, heart block, nausea, neuromuscular weakness, respiratory depression
Drug to Drug Interactions
May enhance action of Ca channel blockers.
2 g IV bolus for torsades
2 g/250 cc N/S infused over 20 minutes in asthma
Max bolus = 4 grams
50 mg/kg for pediatrics, Max 2.0 g
See BCEHS Pediatric Dosage (BCEHS Peds Dosages) recommendations for age and weight-appropriate dosing information.