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stimulation resulting in bronchodilation and some degree of vasodilation.
effect – especially with repeated doses.
Little or no α stimulation.
Onset - 5 minutes
Peak - < 1.5 to 2 hours
Half-life - 3.8 hours
Duration - 3 to 8 hours
Bronchospasm associated with asthma, bronchitis or emphysema
Bronchospasm & wheezing secondary to other causes, such as anaphylaxis
Hemodynamically significant tachyarrhythmias.
Coronary disease (increased MVO
COPD pts with degenerative heart disease.
Diabetes (decreases the effectiveness of insulin).
Restlessness, apprehension, fear, weakness, vertigo
Nausea and vomiting.
Paradoxical worsening of respiratory distress, pulmonary edema.
Sweating, pallor, flushing.
Discontinue if repeated doses result in signs of Salbutamol toxicity - i.e. if H.R > 150 (>200 in pediatric patients) or if severe tremor or ventricular dysrhythmias develop.
5 mg in 5 ml NS or H
O nebulized (with O
at 6-8 L/min.) - repeat doses back to back prn - watch for signs of toxicity.
0.1 mg/kg nebulized in 2-5 cc NS
Also a common prescription drug – usual dose by MDI is 100 mcg inhaled.
selectivity is lost with high doses.
10 mg of Salbutamol may lower serum potassium by as much as 1-1.5 mEq/L (normal K is 3.5-5.0 mEq/L) and is sometimes ordered in the setting of hyperkalemia.